Protease Inhibitors and Phosphatase Inhibitors
Medchemexpress LLC HY-108439 5mg Medchemexpress, Neurodazine CAS:937807-66-4 Purity:>98%
Medchemexpress, HY-108439 5mg Neurodazine CAS:937807-66-4 Neurodazine is an imidazole-based small molecule, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways. Neurodazine selectively suppresses astrocyte differentiation of P19 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Mps1tK InhIbItr 25mg
An inhibitor of Mps1/TTK (IC50 = 5.8 nM); inhibits Mps1 phosphorylation of KNL1 and increases the rate of mitosis at 100 nM; increases the number of missegregated chromosomes at 50 and 100 nM; inhibits colony formation of DLD1, HCT116, and U2OS cells (IC50s = 24.6, 20.1, and 20.6 nM, respectively)
Haematologic Technologies Inc PPACK 25MG
Inhibitor, Phe-Pro-Arg Chloromethylketone (PPACK), 25 milligrams, Use: Tri-peptide chloromethylketones are used to irreversibly inhibit various serine proteases, Research use only, Supplied lyophilized, store at 4 degrees Celsius.
Cayman Chemical STAT5 InhIbItr 10mg
A cell-permeable, nonpetidic nicotinoyl hydrazone that selectively suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity)
Cayman Chemical Heat Shock Protein Inhibitor
A benzylidene lactam compound that prevents the synthesis of inducible Hsps Hsp105, Hsp72, and Hsp40; at 100 μM, inhibits the development of thermotolerance in COLO 320 DM cells
Cayman Chemical mP-2mP-9 InhIbItr II 500ug
A dual inhibitor of MMP-2 and MMP-9 (IC50s = 17 and 30 nM, respectively); suppresses lung colonization of Lewis lung carcinoma cells and inhibits tumor-induced angiogenesis, tumor growth, and liver metastasis in mice
FOCUS BIOMOLECULES Biochemical Reagents, BRM014, BRM / BRG1 ATPase inhibitor, CAS 2270879-17-7, 98% by HPLC/NMR (Conforms)
Biochemical Reagents, BRM014, BRM / BRG1 ATPase inhibitor, CAS 2270879-17-7, 98% by HPLC/NMR (Conforms), BRM014 is an allosteric dual inhibitor of BRM and BRG1 (IC50less than5 nM for both). It downregulated BRM-dependent gene expression and displayed antiproliferative activity in a BRG1-mutant-lung-tumor xenograft model after oral administration. Inhibition of BRG1/BRM ATPase by BRM014 inhibits chromatin openness. For example, it reduced DNA accessibility to core regulatory factors (RUNX1, LM01 and MEIS1) at transcription factor PU.1 sites in AML cells. P583 cells formed markedly large spheroids when treated with BRM014. Cell permeable and active in vivo.
Research Products International Corp PEPSTATIN A, 5 MG
An inhibitor of aspartic proteases. Forms a 1:1 complex with proteases such as pepsin, renin and cathepsin D. Highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases.
Biotang Inc APROTININ, 10 MG,P-744,CAS # 9087-70-1. C284H432N84O79S7 with mol. wt. of 6511.44. Powder with purity of > 95%. Shipped at room temperature.
APROTININ, 10 MG,P-744,CAS # 9087-70-1. C284H432N84O79S7 with mol. wt. of 6511.44. Powder with purity of > 95%. Shipped at room temperature.
Apexbio Technology LLC Boceprevir 394730-60-0 5mg
Boceprevir is an oral inhibitor targeting hepatitis C virus (HCV) NS3 protease an enzyme essential for processing viral polyproteins during HCV replication The compound binds directly and reversibly to the NS3 enzyme s active site forming a covalent adduct through its ketoamide functionality Cell-based replicon assays demonstrated that boceprevir inhibits HCV replication in cultured hepatocytes with an IC90 of approximately 350 nM In preclinical studies boceprevir exhibited favorable selectivity towards HCV NS3 relative to human neutrophil elastase Commonly boceprevir is used in research investigating HCV replication mechanisms and NS3 enzyme function as well as in antiviral combination assays involving interferon-based regimens
Cayman Chemical ProstaglndIn E2 InhIbItr 3 5mg
An mPGES-1 inhibitor (IC50 = 0.2 µM); selective for mPGES-1 over COX-1, COX-2, 5-LO, and sEH in cell-free assays at 10 µM; inhibits IL-1β-induced production of PGE2 in A549 cells and LPS-induced IL-6 and PGE2 production in J774A.1 macrophages at 10 and 1 µM, respectively; inhibits the formation of 5-LO products, including LTB4 and 5-H(p)ETE, induced by A23187 alone or with arachidonic acid and A23187 (IC50s = 4.9 and 5.2 µM, respectively); prevents leukocyte infiltration into the peritoneal fluid in a mouse model of zymosan-induced peritonitis at 10 mg/kg
Abcam Suberoyl bis-hydro x amic acid (SBHA), HDAC inhibitor, 100MG
MW 204.22 Da, Purity >98%. Potent, non-selective HDAC inhibitor (ID₅₀ values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (ab142387). Induces apoptosis. Shows antiproliferative effects (IC₅₀ = 15 μM, HeLa cells).
The product is subject to the following: Abcam Restricted Use Statement
Abcam KU-60019, ATM kinase inhibitor, 50MG
MW 547.7 Da, Purity >98%. Potent, highly selective ATM kinase inhibitor (IC₅₀ = 6.3 nM). Inhibits migration and invasion of glioma cells. Shows similar target selectivity to KU-55933 (ab120637). Shows radiosensitizing effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical FerroptosIs InhIbItr D1 1mg
A free radical scavenger and an inhibitor of ferroptosis; scavenges 41.27% of DPPH radicals in a cell-free assay at 0.4 µM; inhibits erastin-induced lipid peroxidation in HT-1080 cells at 0.5 µM and erastin-induced ferroptosis in the same cells (IC50 = 22 nM); reduces infarct volume and improves neurological deficits in a mouse model of transient MCAO-induced ischemic brain injury at 5 mg/kg
Abcam RWJ-60475 (AM)3, CD45 tyrosine phosphatase inhibitor, 1MG-SLD
MW 620.4 g/mol, Purity >95%. CD45 tyrosine phosphatase inhibitor (IC₅₀ = 2 μM). Cell permeable. Inhibits ADP induced platelet aggregation and IL-2 production in vitro.
The product is subject to the following: Abcam Restricted Use Statement